After the zoo's polar bear trainer is murdered unexpectedly, officials are quick to point the finger at the polar bear, but Shawn believes the animal to be innocent.
The Yin/Yang trilogy comes to a thrilling close as Shawn and Gus race to save a woman kidnapped by Yin. Only this time, they are forced to use Yang's knowledge of Yin to solve the case.
For the first time in years, Monk has made progress in therapy. But when Natalie discovers that Trudy may be alive, she risks unraveling her boss completely.
Natalie asks Randy to be her date to her brother's wedding. But when he's run down in the parking lot, Monk steps in to figure out what exactly is going on.
After a vicious truck stop attack, Monk awakens with amnesia in a desert hamlet, married to a domineering loon, and suspicious of the circumstances surrounding the hasty departure of a waitress.
While investigating a murder, Stollemeyer gets into an argument with a cop at the scene who snidely tells him he has been seeing his wife. As a result the crime scene was deemed contaminated.
Despite everyone's disbelief that a hero making the news is actually a coldblooded killer, Adrian tries to prove that a celebrity astronaut is responsible, despite an airtight alibi.
Monk must face his fears of dentists after Randy believes he witnesses a murder while under anasthetics. The problem is, the case is connected to a recent armored car robbery.
Monk is summoned to jury duty against his wishes and must solve two crimes: he has to convince the jury the defendant is not guilty, and solve the mystery of a corpse outside the jury room's window.
Monk and Natalie go to Berkeley for Monk's 25th college reunion, but are sidetracked when Stottlemeyer shows up asking for their help on the recent homicide of a retired clinic nurse.
Dr. Kroger questions his abilities after a patient becomes the prime suspect in a murder. He decides to retire but a distressed Monk is convinced someone else is responsible.