A former San Francisco police detective suffering from an extreme case of obsessive-compulsive disorder is called in to investigate an apparent assassination attempt of a mayoral candidate in which one of his bodyguards is killed.
With an introduction to Monk's talent, his phobia's, and need for an assistant, Monk investigates the murder of the candidate bodyguard and a political worker. He determines the candidate was not the intended target.
When a woman drives off the road to her death, her body is mysteriously found the next morning by a psychic known for fudging the truth. Monk must discover if she's telling the truth this time, or else let a murderer go free.
A judge is murdered while placing a 911 call, but before she dies she names her attacker - notorious criminal Dale Biederbeck. The problem is, "Dale the Whale" is over 800 pounds and hasn't left his bed in years.
While on vacation at a resort, Benjy claims he witnessed a murder. Monk believes him, but with no body and the cleanest crime scene Monk has ever seen, it's going to be hard to convince everybody else.
Renowned philanthropist Henry Rutherford is killed when a minor earthquake rocks the city and sends a display case falling on top of him. But when Monk examines the scene, he finds clues that suggest foul play.
When a powerful CEO and his wife are shot to death in a deserted parking lot, the police investigate the husband's enemies. But Monk thinks it's all about the wife and the affair she was having with a handsome young ballplayer.
The world's oldest man dies the day before his birthday, and everyone but Stottlemeyer's wife, Karen, thinks it's just the result of old age. Karen enlists Monk's help to figure out what really happened.